Ariya Purity GOS Galactooligosaccharides 100g

Galactooligosaccharides (GOS) are a group of carbohydrates made up of a chain of galactose units. They are produced commercially from lactose using the enzyme beta-galactosidase (Bhatia, et al., 2015). GOS are similar in structure to oligosaccharides that occur naturally in human milk. Their unique chemical structure enables them to escape digestion by both salivary and intestinal enzymes, allowing them to pass undigested into the colon where they act as prebiotics, stimulating the growth and activity of beneficial bacteria (Bhatia, et al., 2015).

WHAT IS THE CLINICAL RELEVANCE OF GALACTOOLIGOSACCHARIDES
Clinically, GOS have been trialed for use in numerous conditions including constipation, diarrhoea, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), colon and rectal cancers, leaky gut and associated conditions such as asthma, eczema, allergic rhinitis, food allergies and mental health conditions
(WebMD, 2018).

In the literature, GOS may also be referred to as transoligosaccharides (TOS) or trans-
galactooligosaccharides (TGOS) (Bhatia, et al., 2015).

A number of clinical trials have found GOS to be beneficial in the treatment of gastrointestinal conditions such as constipation and IBS. The effect of GOS on patients with IBS appears to be similar to that found with supplementation of Bifidobacteria spp, with positive changes noted in stool consistency, flatulence, abdominal pain/discomfort, bloating/distension, bowel movement difficulty, as well as anxiety in diarrhea predominant IBS (Silk, Davis, Vulevic, Tzorzis, & Gibsob, 2009). These improvements have been attributed to the bifidogenic effect, which has been demonstrated in various clinical trials using different
concentrations of GOS (Silk, Davis, Vulevic, Tzorzis, & Gibsob, 2009) (Nittynen, Kajander, & Korpela, 2007).
GOS and other prebiotics, such as fructo-oligosaccharides and lactulose have been demonstrated to prevent bacterial colonisation and pathogen invasion of the gastrointestinal tract. GOS is similar in structure to cell surface glycoconjugates that are used by pathogens to adhere to the gastrointestinal wall.
In addition, in vivo studies have shown GOS to directly modulate expression of goblet cell secretory products and golgi sulfotransferase which together form barrier-enhancing sulfomucins. Through its role in preventing and modulating gastrointestinal infection and inflammation, GOS may also assist in preventing downstream consequences of leaky gut such as allergies, autoimmune diseases, mental health

conditions and metabolic syndromes (Bhatia, et al., 2015).

Free of gluten, crustacean, egg, fish, shellfish, lupin, peanut and tree nuts, sesame, soy and sulfites
Contains up to a maximum of 10% dextrose and 23% maximum of lactose, with >70% of GOS
Non-GMO, Halal and Kosher-certified
Vegetarian friendly

Dosage

3 - 15 g daily
Increase dosage slowly over time to minimise side effects

Warnings

Contains lactose Contains products derived from dairy
Dietary supplements should not replace a balanced diet